Sr. Associate Scientist 2 / Principal Associate Scientist back to job list
Mosaic Biosciences is a discovery and preclinical development company that partners with biopharmaceutical companies to discover novel protein and antibody therapeutics. Our experienced and dedicated research teams collaborate with our partners to design, manage, and execute research programs to rapidly advance clinical candidates, starting at any point from early discovery into preclinical development. 
Position Overview:
We are seeking an experienced and motivated Senior Associate Scientist 2/ Principal Associate Scientist to join our growing Antibody Discovery & Optimization (ADO) team. The successful candidate will participate in the construction, validation, and screening of surface-displayed antibody libraries. The ideal candidate will have in-depth, hands-on expertise in all steps of display technology (yeast, phage, or mammalian), including DNA library construction, FACS, ELISA, and NGS.

Key Responsibilities:
  • Design and execute antibody discovery and affinity maturation campaigns using yeast and phage display
  • Construct libraries using standard molecular biology techniques
  • Conduct high-throughput screening (HTS) of antibody display campaign outputs using ELISA and flow cytometry
  • Prepare and analyze NGS samples
  • Analyze and interpret experimental data, and clearly communicate findings in presentations
  • Work on multiple projects simultaneously, ensuring timely delivery of potential therapeutic leads with appropriate guidance
  • Document data in an electronic lab notebook in an organized manner
  • Innovate and establish new strategies to optimize existing protocols
Qualifications:
  • BS in Biological/Chemical Engineering, Molecular Biology, Biochemistry, Immunology or related discipline with 6-8 + years of industry experience
  • Direct experience with phage or yeast display systems required
  • Direct experience in protein engineering
  • In-depth knowledge and hands-on experience with molecular biology techniques, including RT-PCR, PCR, overlap extension PCR, cloning, primer design, mutagenesis methods, and in-silico DNA construct design
  • Experience with flow cytometry
  • Experience in cloning, expression, and purification of proteins/antibodies in bacterial, yeast, and mammalian cells
  • Experience with NGS-based workflows, NGS sequencing, and data analysis is a plus
  • Willingness to learn and adopt new techniques
Location: This is a full-time position in Boulder, CO with in-person work in our labs.

Compensation Range: $80,000- $100,000

As a member of our team, you will be eligible for comprehensive, competitive, flexible benefits that include health and dental insurance, disability and life insurance, 401k with company match, and bonus opportunities based on company success.

If you want to join us in discovering life-saving protein and antibody therapeutics, please apply by completing the application below.

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