Mosaic Biosciences
Sr. Scientist I, Antibody Discovery and Optimization back to job list
We are hiring a Sr. Scientist I to join Mosaic's Antibody Discovery and Optimization team in Boulder, Colorado. The successful candidate will serve as a technical lead on the construction, validation, and screening of surface-displayed antibody libraries and will help shape the scientific strategy of client programs. The ideal candidate has deep, hands-on expertise across display technology (yeast required, phage preferred), including DNA library construction, FACS, and NGS analysis, and has a track record of independently solving complex discovery challenges.

Responsibilities
  • Independently design and execute complex antibody discovery and affinity maturation campaigns using yeast and phage display, and serve as the technical lead for projects or program components of moderate to high complexity
  • Construct and optimize libraries using PCR, RT-PCR, Golden Gate/Gibson assembly, and mutagenesis in phage and yeast display vectors
  • Direct high-throughput screening (HTS) of antibody display campaign outputs using flow cytometry, including selection and refinement of methods and evaluation criteria
  • Analyze and interpret complex experimental data, integrating multidisciplinary perspectives to guide project-level scientific decisions
  • Serve as a key scientific point of contact for external partners, preparing and delivering presentations, updates, and reports, and building strong collaborative relationships
  • Manage multiple projects simultaneously, coordinating workflows, timelines, and deliverables, proactively identifying risks to scope, cost, or schedule, and driving mitigation plans to ensure timely delivery of therapeutic leads
  • Collaborate cross-functionally with internal teams such as Protein Science, Protein Engineering, Sequencing, and Project Leadership to plan, execute, and align on project strategies, timelines, and deliverables
  • Contribute technical input to proposal development, including feasibility assessments and resource estimation, in partnership with Commercial and Project Leadership
  • Mentor and train scientists, and lead a small group of scientists as needed
  • Maintain organized, high-quality documentation in an electronic lab notebook (ELN) and LIMS system, and uphold standards for quality and reproducibility
  • Innovate and establish new strategies and approaches to address challenging targets
  • Stay current with advances in antibody discovery and display technologies, bringing innovative approaches to the team
Requirements
  • PhD in molecular biology, biochemistry, or a related scientific discipline with 4+ years of related experience (academic postdoctoral and/or industry); Or MS with 8+ years related industry experience.
  • Demonstrated experience in antibody discovery
  • Extensive, direct experience with yeast display systems
  • In-depth knowledge and hands-on experience with molecular biology techniques, including RT-PCR, PCR, overlap extension PCR, cloning, primer design, and in-silico DNA construct design
  • Strong experience with flow cytometry and FACS-based selections
  • Experience in cloning and expression and antibodies/libraries in bacterial and yeast cells
  • Demonstrated ability to work independently, exercise sound scientific judgment, and lead projects of moderate to high complexity
  • Strong project leadership and organizational skills, including managing timelines, coordinating workflows, and overseeing program execution
  • Experience preparing and delivering scientific presentations to external collaborators and partners
  • Excellent written and verbal communication skills, with the ability to present findings clearly and concisely
  • Willingness to learn and adopt new techniques
Location and compensation
This is a full-time position in Boulder, CO with in-person work in our labs.

Base Salary Range: $120,000 - $135,000
As a member of our team, you will be eligible for comprehensive, competitive, flexible benefits that include health and dental insurance, disability and life insurance, 401k with company match, and bonus opportunities based on company success.
 

If you want to join us in discovering life-saving protein and antibody therapeutics, please apply by completing the application below.

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Describe your hands-on experience with yeast surface display for antibody discovery or optimization. What parts of the workflow have you personally performed (e.g., library transformation, selection, FACS sorting)?*
Describe your experience designing, constructing, or working with antibody libraries. What types have you worked with (e.g., naïve, immune, synthetic, semi-synthetic), and what was your role?*
Describe an antibody discovery or optimization campaign you led or served as technical lead on. What was the goal of the project, which experimental approaches did you use, and what was your role in identifying and characterizing candidates? If applicable, include how you communicated results to external partners or collaborators.*
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